Trusted for the effective management of moderate to severe acute postoperative pain.
Generic Name: Ketorolac Tromethamine Injection (IV/IM)
Category: Pain Management / NSAIDs (Non-Steroidal Anti-Inflammatory Drug)
Product Description
Panache® is a potent non-steroidal anti-inflammatory drug (NSAID) indicated for the short-term management of moderate to severe acute pain, particularly acute postoperative pain. By inhibiting prostaglandin synthesis, it provides rapid and effective analgesia while helping to reduce inflammation.
With analgesic efficacy comparable to opioids for the management of moderate to severe acute pain, Panache offers an effective non-opioid treatment option. It is widely used in postoperative care, emergency departments, and trauma settings as part of multimodal pain management strategies.
Panache also supports opioid-sparing pain management by helping reduce opioid requirements while maintaining effective pain control, thereby minimizing opioid-related adverse effects.
Indications
Panache® is indicated for the short-term management of moderate to severe acute pain, including:
- Acute postoperative pain
- Musculoskeletal pain and trauma
- Dental pain, including pain following dental procedures
- Renal colic pain
- Other moderate to severe acute pain requiring short-term NSAID therapy
Key Benefits
- Rapid onset of pain relief
- Potent analgesic effect
- Reduces inflammation alongside pain
- Suitable for short-term management of moderate to severe pain
- Trusted quality from Superior Pharmaceuticals Ltd.
Contraindications
Panache (Ketorolac Tromethamine Injection) is contraindicated in patients with:
- Hypersensitivity to ketorolac tromethamine, aspirin, or other non-steroidal anti-inflammatory drugs (NSAIDs).
- Active peptic ulcer disease, recent gastrointestinal bleeding or perforation, or a history of recurrent peptic ulcer disease.
- Advanced renal impairment or patients at risk of renal failure due to volume depletion.
- Suspected or confirmed cerebrovascular bleeding, hemorrhagic diathesis, incomplete haemostasis, or patients at high risk of bleeding.
- Use as a prophylactic analgesic before major surgery due to the increased risk of bleeding.
- Labour and delivery, as ketorolac may adversely affect fetal circulation and inhibit uterine contractions.
- Concurrent use with other NSAIDs (including COX-2 inhibitors) or aspirin because of the increased risk of serious adverse effects.
- Concomitant treatment with probenecid or pentoxifylline.
- Neuraxial (epidural or intrathecal) administration, as the formulation contains alcohol and is not intended for these routes.
- Children below 16 years of age (where safety and efficacy have not been established, depending on local regulatory approval).
Important: Panache is intended for short-term management of acute moderate to severe pain and should not be used for more than 5 days due to the increased risk of serious gastrointestinal, renal, cardiovascular, and bleeding complications.
Dosage and Administration
Adults
- Recommended Dose: 30 mg every 6 hours, or a single 30 mg dose, as clinically indicated.
- Maximum Daily Dose: 120 mg.
- Duration of Therapy: Treatment should not exceed 5 days.
Note: Panache® is intended for short-term use only. Dosage should be individualized based on the patient’s clinical condition and administered under the supervision of a qualified healthcare professional. Please refer to the full Prescribing Information for complete dosing recommendations, contraindications, warnings, and precautions.