Category: ANTI MALARIA
Product Description
Sumether® 80/480 Tablets combine Artemether 80 mg and Lumefantrine 480 mg, an artemisinin-based combination therapy (ACT) recommended for the treatment of acute uncomplicated Plasmodium falciparum malaria. Artemether rapidly reduces parasite load, while Lumefantrine eliminates residual parasites, reducing the risk of treatment failure and resistance.
This fixed-dose combination provides rapid symptom relief, high cure rates, and convenient dosing for adults and children weighing 35 kg and above.
Indications
Sumether® 80/480 Tablets are indicated for:
- Treatment of acute uncomplicated Plasmodium falciparum malaria
- Treatment of uncomplicated malaria caused by mixed infections including P. falciparum
- Treatment of malaria in areas with chloroquine-resistant P. falciparum
- Completion of therapy following initial parenteral antimalarial treatment when appropriate
Contraindications
Sumether® 80/480 Tablets are contraindicated in patients with:
- Hypersensitivity to artemether, lumefantrine, or any component of the formulation.
- Severe or complicated malaria, which requires parenteral treatment.
- Congenital long QT syndrome or a family history of QT prolongation.
- Concomitant use of medicines known to significantly prolong the QT interval.
- Concomitant use of potent CYP2D6 substrate medications where contraindicated.
Use with caution in patients with electrolyte abnormalities, severe hepatic impairment, or those receiving medicines that affect cardiac rhythm.
Dosage and Administration
Sumether® should be taken with food or a milk-containing drink to enhance lumefantrine absorption.
Adults and Children ≥35 kg
- One tablet at diagnosis.
- One tablet after 8 hours.
- Then one tablet twice daily (morning and evening) for the next 2 days.
This completes a 6-dose regimen over 3 days (total of 6 tablets).
If vomiting occurs within 1 hour of administration, the dose should be repeated. Patients should complete the full treatment course even if symptoms improve earlier.
Key Features
- WHO-recommended artemisinin-based combination therapy (ACT)
- Rapid parasite clearance with sustained antimalarial activity
- Effective against uncomplicated Plasmodium falciparum malaria
- Convenient 3-day, 6-dose treatment regimen
- High cure rates with reduced risk of resistance
- Suitable for adults and children weighing 35 kg and above
- Best absorbed when taken with food or milk for optimal therapeutic efficacy