Category: ANTI BIOTICS
Product Description
Supermentin® is a broad-spectrum antibiotic combining Amoxicillin, a penicillin-class antibacterial agent, with Clavulanic Acid, a β-lactamase inhibitor. This combination extends the antibacterial spectrum of amoxicillin by protecting it against degradation by β-lactamase-producing bacteria, making it effective against a wide range of Gram-positive and Gram-negative pathogens.
Available in 625 mg tablets (500 mg/125 mg), 1 g tablets (875 mg/125 mg), and 228 mg/5 mL oral suspension (200 mg/28.5 mg), Supermentin® is indicated for the treatment of susceptible bacterial infections in adults and children.
Indications
Supermentin® is indicated for the treatment of infections caused by susceptible microorganisms, including:
- Acute bacterial sinusitis
- Acute otitis media
- Acute exacerbations of chronic bronchitis
- Community-acquired pneumonia
- Upper and lower respiratory tract infections
- Urinary tract infections, including cystitis and pyelonephritis
- Skin and soft tissue infections, including cellulitis, infected wounds, and animal bites
- Severe dental infections, including dental abscess with spreading cellulitis
- Bone and joint infections, including osteomyelitis
- Intra-abdominal infections (in combination with appropriate antimicrobial therapy where indicated)
- Gynaecological infections caused by susceptible organisms
Contraindications
Supermentin® is contraindicated in patients with:
- Known hypersensitivity to amoxicillin, clavulanic acid, penicillins, or any component of the formulation.
- A history of severe immediate hypersensitivity reactions (e.g., anaphylaxis) to other β-lactam antibiotics, including cephalosporins, carbapenems, or monobactams.
- Previous cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid therapy.
- Infectious mononucleosis, where administration of amoxicillin is associated with a higher incidence of skin rash.
Dosage and Administration
Supermentin® should be administered at the start of a meal to improve absorption and minimise gastrointestinal side effects. Dosage should be based on the severity of infection, patient age, body weight, and renal function.
Adults and Children ≥40 kg
Supermentin® 625 mg Tablets
- One tablet every 8 hours (three times daily).
Supermentin® 1 g Tablets
- One tablet every 12 hours (twice daily) for moderate to severe infections.
Children (<40 kg)
Supermentin® 228 mg/5 mL Oral Suspension
- 25–45 mg/kg/day (based on the amoxicillin component) in two divided doses, depending on the severity and type of infection.
- Higher doses may be recommended for selected infections such as acute otitis media, sinusitis, or community-acquired pneumonia, according to clinical guidelines.
Duration of Therapy
- Treatment is typically 5–14 days, depending on the infection and clinical response.
- Therapy should not usually exceed 14 days without clinical reassessment.
- Broad-spectrum antibacterial activity
- Combines Amoxicillin with Clavulanic Acid for enhanced β-lactamase stability
- Effective against β-lactamase-producing organisms
- Available in adult tablet and paediatric suspension formulations
- Suitable for respiratory, urinary, skin, soft tissue, bone, and dental infections
- Convenient twice-daily (1 g) or three-times-daily (625 mg) dosing
- Trusted choice for community-acquired bacterial infections and antimicrobial stewardship initiatives